Reference - Detail
| RRC ID | 86454 |
|---|---|
| Author | Raimondo MG, Mohammadian H, Angeli MR, Alivernini S, Fedorchenko V, Huang K, Demmler R, Rhein P, Xu C, Li YN, Micheroli R, Winter Z, Rigau AR, Anchang CG, Soare A, Luber M, Labinsky H, Chang J, Günther C, Fearon U, Veale DJ, Ciccia F, Rech J, Sticherling M, Bäuerle T, Distler JHW, Kurowska-Stolarska MS, Mack M, Ekici AB, Croft AP, Distler O, Maric HM, Ospelt C, Cañete JD, D'Agostino MA, Schett G, Rauber S, Ramming A. |
| Title | Skin-derived myeloid precursors and joint-resident fibroblasts spread psoriatic disease from skin to joints. |
| Journal | Nat Immunol |
| Abstract |
Psoriatic disease initially affects the skin and later extends to the joints. Here, we show a two-step process that orchestrates the spread of inflammation from the skin to the joints. Induction of psoriatic skin disease in photoconvertible mice, followed by sequencing and computational characterization of skin-derived cells in the joints, was used to identify a population of CD2+MHC-II+CCR2+ myeloid precursors that builds a skin-derived myeloid cell compartment in the joints. Single-cell cross-species reference mapping and mitochondrial variant tracing showed an orthologous human cell population. Interactome analysis of the joints showed that in a second step, resident regulatory CD200+ fibroblasts regulate the priming of CD2+MHC-II+CCR2+ myeloid precursors, which subsequently control IL-17 expression in T cells. Hence, the spread of inflammation requires a distinct migratory myeloid precursor population and a permissive local tissue environment, similar to tumor metastasis. |
| Volume | 27(1) |
| Pages | 35-47 |
| Published | 2026-1-1 |
| DOI | 10.1038/s41590-025-02351-z |
| PII | 10.1038/s41590-025-02351-z |
| PMID | 41482544 |
| PMC | PMC12764428 |
| MeSH | Animals Cell Movement Disease Models, Animal Fibroblasts* / immunology Fibroblasts* / metabolism Fibroblasts* / pathology Humans Interleukin-17 / metabolism Joints* / immunology Joints* / pathology Mice Myeloid Cells Myeloid Progenitor Cells* / immunology Myeloid Progenitor Cells* / metabolism Psoriasis* / immunology Psoriasis* / pathology Skin* / immunology Skin* / pathology T-Lymphocytes / immunology |
| IF | 20.479 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | News |
| Total number of mentions | 37 |
| Altmetric score changes over past 6months | 104.6 |
| Resource | |
| Mice | RBRC09257 RBRC05737 |