Reference - Detail
| RRC ID | 86596 |
|---|---|
| Author | Iinuma T, Kurokawa T, Aoki T, Onodera A, Fukazawa T, Yamada D, Kitahara G, Okoshi M, Yamaguchi M, Okura H, Sasaki S, Sasako Y, Kira S, Sharif J, Tsuchiyama Y, Kobayashi M, Kobayashi N, Horikoshi T, Inaba Y, Hanaoka H, Okamoto Y, Hanazawa T, Koseki H, Motohashi S. |
| Title | Allogeneic iPSC-derived iNKT cells in recurrent head and neck cancer: a phase 1 trial. |
| Journal | Nat Commun |
| Abstract |
Invariant Natural killer T (iNKT) cells exhibit cytotoxic activity and immunomodulatory functions and have gained interest in cancer immunotherapy. We conducted a phase 1, first-in human clinical trial to evaluate the safety and efficacy of clinical-grade allogeneic iNKT cells generated from induced pluripotent stem cells (iPSC-iNKT cells) in patients with recurrent head and neck cancer (jRCT2033200116). The primary endpoint was the incidence of dose-limiting toxicity (DLT). The secondary endpoints were to assess safety and efficacy, as well as to evaluate immunological dynamics. iPSC-iNKT cells were administered intra-arterially to 10 patients. One subject developed grade 3 skin rash at the second dose, identified as DLT. No other severe adverse events were observed in any patients. Tumor progression was suppressed in two patients, in whom clonal expansion of memory- and effector-phenotype CD8+ T cells was observed, along with activation of the IFN-γ signaling pathway. Here, we show that iPSC-iNKT cells are safe and possess therapeutic potential as an immunotherapy for solid tumors. |
| Volume | 16(1) |
| Pages | 11666 |
| Published | 2025-11-26 |
| DOI | 10.1038/s41467-025-66801-w |
| PII | 10.1038/s41467-025-66801-w |
| PMID | 41298491 |
| PMC | PMC12749447 |
| MeSH | Adult Aged CD8-Positive T-Lymphocytes / immunology Female Head and Neck Neoplasms* / immunology Head and Neck Neoplasms* / pathology Head and Neck Neoplasms* / therapy Humans Immunotherapy / methods Immunotherapy, Adoptive* / adverse effects Immunotherapy, Adoptive* / methods Induced Pluripotent Stem Cells* / cytology Induced Pluripotent Stem Cells* / immunology Interferon-gamma / metabolism Male Middle Aged Natural Killer T-Cells* / immunology Natural Killer T-Cells* / transplantation Neoplasm Recurrence, Local* / immunology Neoplasm Recurrence, Local* / therapy |
| IF | 12.121 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 98 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | OP9/N(RCB2926) OP9/N-DLL1(RCB2927) |