Reference - Detail
| RRC ID | 865 |
|---|---|
| Author | Takeda O, Takechi S, Katoh T, Yamaguchi T. |
| Title | The Role of dihydropyrazines in accelerated death of Escherichia coli on addition of copper(II). |
| Journal | Biol Pharm Bull |
| Abstract |
Dihydropyrazines (DHPs), which are derived from sugars, inhibit the growth of Escherichia coli. Addition of copper(II) ion (Cu2+) accelerates the effect of DHPs, resulting in cell death. Investigation of the lethal effect in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains and radical scavengers suggested that the cytotoxic and genotoxic damage was caused by radical species (hydroxyl, superoxide anion, and carbon-centered radicals) generated from reaction of DHPs with Cu2+. |
| Volume | 28(7) |
| Pages | 1161-4 |
| Published | 2005-7-1 |
| DOI | 10.1248/bpb.28.1161 |
| PII | JST.JSTAGE/bpb/28.1161 |
| PMID | 15997090 |
| MeSH | Copper / pharmacology* Drug Synergism Escherichia coli / drug effects* Pyrazines / pharmacology* |
| IF | 1.863 |
| Times Cited | 16 |
| WOS Category | PHARMACOLOGY & PHARMACY |
| Resource | |
| Prokaryotes E. coli | ME8079(AB1157) ME8087(AB2463) ME8303(UM197) ME8299(UM119) ME8993(QC774) |