| RRC ID |
86633
|
| Author |
Sakimoto S, Takigawa T, Oguchi A, Yoshihara M, Sekito S, Ueda C, Shiraki A, Shiki K, Yamaguchi K, Fukushima Y, Kitajima S, Murakawa Y, Quantock AJ, Nishida K.
|
| Title |
Endothelial stem cells of the retinal vasculature reside in the optic nerve.
|
| Journal |
Nat Commun
|
| Abstract |
Cells of the retina, photoreceptors especially, are highly metabolically active with substantial energy requirements. Accordingly, the effective delivery of oxygen and nutrients to the retina via the retinal vasculature is key to tissue function. Indeed, a disturbed retinal blood supply, especially if prolonged, can result in a loss of vision. Vascular endothelial cells, which form the inner lining of blood vessels, are pivotal in ensuring a healthy blood circulation in many tissues, including the light-sensitive retina at the back of the eye. However, the mechanism by which vascular endothelial cells maintain a functional retina (and aid the healing of a damaged one) is not understood. Here, through single-cell RNA sequencing, colony-forming assays and lineage tracing analysis, we provide data that point to a new regulatory system by which vascular endothelial cells are supplied to the retina by a reservoir of stem/progenitor cells in the optic nerve.
|
| Volume |
17(1)
|
| Pages |
606
|
| Published |
2026-1-23
|
| DOI |
10.1038/s41467-025-68201-6
|
| PII |
10.1038/s41467-025-68201-6
|
| PMID |
41577708
|
| PMC |
PMC12830651
|
| MeSH |
Animals
Endothelial Cells* / cytology
Endothelial Progenitor Cells* / cytology
Endothelial Progenitor Cells* / metabolism
Male
Mice
Mice, Inbred C57BL
Optic Nerve* / cytology
Optic Nerve* / metabolism
Retina / cytology
Retina / metabolism
Retinal Vessels* / cytology
Retinal Vessels* / metabolism
Single-Cell Analysis
|
| IF |
12.121
|
| Resource |
| Human and Animal Cells |
OP9(RCB1124) |
