Reference - Detail
| RRC ID | 86649 |
|---|---|
| Author | Jeffrey Stedehouder, Katerina Panti, Yangfan Peng, Charlotte J Stagg, Andrew Sharott |
| Title | Higher-Order Thalamus is Pivotal in Schizophrenia-Associated Pathophysiology |
| Abstract |
Synaptic dysfunction has been proposed as cellular pathophysiology underlying schizophrenia, yet the brain-wide distribution of dysfunctional circuits at single-neuron resolution has remained unknown. Here, we perform comprehensive multi-probe electrophysiological investigations in vivo in the Grin2a+/- preclinical model for schizophrenia and control animals, recording across ~45 brain regions spanning cortex, striatum, hippocampus, and thalamus. Mutants displayed distributed and graded alterations across regions, with prominent activity reductions in higher-order thalamus and cross-parameter alterations across prefrontal cortices, striatum, and hippocampus. Restoration of higher-order thalamic activity in mutants was sufficient to normalize alterations in connected prefrontal cortices and striatum and unexpectedly cascaded distally to hippocampus and sensory cortices. Thus, higher-order thalamus plays a pivotal role in schizophrenia pathophysiology and restoration of a single informed locus could present a potent therapeutic strategy. |
| DOI | 10.64898/2026.01.24.699491 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC02256 |