Reference - Detail
| RRC ID | 86720 |
|---|---|
| Author | Préau L, Lischke A, Merkel M, Oegel N, Weissenbruch M, Michael A, Park H, Gradl D, Kupatt C, le Noble F. |
| Title | Parenchymal cues define Vegfa-driven venous angiogenesis by activating a sprouting competent venous endothelial subtype. |
| Journal | Nat Commun |
| Abstract |
Formation of organo-typical vascular networks requires cross-talk between differentiating parenchymal cells and developing blood vessels. Here we identify a Vegfa driven venous sprouting process involving parenchymal to vein cross-talk regulating venous endothelial Vegfa signaling strength and subsequent formation of a specialized angiogenic cell, prefabricated with an intact lumen and pericyte coverage, termed L-Tip cell. L-Tip cell selection in the venous domain requires genetic interaction between vascular Aplnra and Kdrl in a subset of venous endothelial cells and exposure to parenchymal derived Vegfa and Apelin. Parenchymal Esm1 controls the spatial positioning of venous sprouting by fine-tuning local Vegfa availability. These findings may provide a conceptual framework for understanding how Vegfa generates organo-typical vascular networks based on the selection of competent endothelial cells, induced via spatio-temporal control of endothelial Kdrl signaling strength involving multiple parenchymal derived cues generated in a tissue dependent metabolic context. |
| Volume | 15(1) |
| Pages | 3118 |
| Published | 2024-4-10 |
| DOI | 10.1038/s41467-024-47434-x |
| PII | 10.1038/s41467-024-47434-x |
| PMID | 38600061 |
| PMC | PMC11006894 |
| MeSH | Angiogenesis* Endothelial Cells* / metabolism Neovascularization, Physiologic* / genetics Veins |
| IF | 12.121 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 36 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | UAS:GFP |