論文 - 詳細
| RRC ID | 86721 |
|---|---|
| 著者 | Seo Y, Mo S, Kim S, Kim H, Park HC. |
| タイトル | Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS. |
| ジャーナル | Int J Mol Sci |
| Abstract |
Tamalin is a post-synaptic scaffolding protein that interacts with group 1 metabotropic glutamate receptors (mGluRs) and several other proteins involved in protein trafficking and cytoskeletal events, including neuronal growth and actin reorganization. It plays an important role in synaptic plasticity in vitro by controlling the ligand-dependent trafficking of group 1 mGluRs. Abnormal regulation of mGluRs in the central nervous system (CNS) is associated with glutamate-mediated neurodegenerative disorders. However, the pathological consequences of tamalin deficiency in the CNS are unclear. In this study, tamalin knockout (KO) zebrafish and mice exhibited neurodegeneration along with oligodendrocyte degeneration in the post-embryonic CNS to adulthood without any developmental defects, thus suggesting the function of tamalin is more important in the postnatal stage to adulthood than that in CNS development. Interestingly, hypomyelination was independent of axonal defects in the CNS of tamalin knockout zebrafish and mice. In addition, the loss of Arf6, a downstream signal of tamalin scaffolding protein, synergistically induced neurodegeneration in tamalin KO zebrafish even in the developing CNS. Furthermore, tamalin KO zebrafish displayed increased mGluR5 expression. Taken together, tamalin played an important role in neuronal and oligodendrocyte survival and myelination through the regulation of mGluR5 in the CNS. |
| 巻・号 | 23(21) |
| 公開日 | 2022-11-2 |
| DOI | 10.3390/ijms232113395 |
| PII | ijms232113395 |
| PMID | 36362204 |
| PMC | PMC9654138 |
| MeSH | Animals Carrier Proteins* / metabolism Central Nervous System / metabolism Membrane Proteins / metabolism Mice Neurons / metabolism Oligodendroglia / metabolism Zebrafish* / genetics Zebrafish* / metabolism |
| IF | 4.556 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | UAS:GFP |