Reference - Detail
| RRC ID | 86744 |
|---|---|
| Author | Kawamura K, Ono K, Mishima E, Hashizume O, Conrad M, Miki H, Funato Y. |
| Title | Cellular Mg2+ decrease causes a distinctive NF-κB-dependent form of cell death. |
| Journal | Cell Rep |
| Abstract |
Mg2+ is an essential cofactor for numerous enzymes, supporting fundamental cellular processes. The phosphatase of regenerating liver (PRL) protein family, frequently upregulated in cancer, inhibits cyclin M (CNNM) Mg2+ efflux transporters. To elucidate the physiological role of PRL in Mg2+ homeostasis at the cellular level, we employed combined genetic knockout and knockdown approaches. PRL deletion led to marked reduction of intracellular Mg2+ levels and triggered extensive cell death. Transcriptomic analysis revealed activation of the NF-κB pathway, and, accordingly, the genetic deletion of NF-κB p65 subunit abrogated cell death. Similarly, CNNM overexpression triggered intracellular Mg2+ decrease, NF-κB activation, and subsequent cell death. Notably, this form of cell death exhibited characteristic morphological features, including actin-driven fiber-like protrusions, distinguishing it from known cell death modalities. Our findings uncover a distinct mode of NF-κB-dependent cell death triggered by intracellular Mg2+ decrease. |
| Volume | 45(2) |
| Pages | 116964 |
| Published | 2026-2-10 |
| DOI | 10.1016/j.celrep.2026.116964 |
| PII | S2211-1247(26)00042-2 |
| PMID | 41671091 |
| MeSH | Animals Cell Death Humans Magnesium* / metabolism Mice NF-kappa B* / metabolism Signal Transduction Transcription Factor RelA / metabolism |
| IF | 8.109 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 1.7 |
| Resource | |
| Human and Animal Cells | J774.1(RCB0434) |
| DNA material | pCAG-HIVgp (RDB04394) pCMV-VSV-G-RSV-Rev (RDB04393) |