Reference - Detail
| RRC ID | 86752 |
|---|---|
| Author | Kitamoto S, Nagao-Kitamoto H, Jiao Y, Gillilland MG 3rd, Hayashi A, Imai J, Sugihara K, Miyoshi M, Brazil JC, Kuffa P, Hill BD, Rizvi SM, Wen F, Bishu S, Inohara N, Eaton KA, Nusrat A, Lei YL, Giannobile WV, Kamada N. |
| Title | The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis. |
| Journal | Cell |
| Abstract |
The precise mechanism by which oral infection contributes to the pathogenesis of extra-oral diseases remains unclear. Here, we report that periodontal inflammation exacerbates gut inflammation in vivo. Periodontitis leads to expansion of oral pathobionts, including Klebsiella and Enterobacter species, in the oral cavity. Amassed oral pathobionts are ingested and translocate to the gut, where they activate the inflammasome in colonic mononuclear phagocytes, triggering inflammation. In parallel, periodontitis results in generation of oral pathobiont-reactive Th17 cells in the oral cavity. Oral pathobiont-reactive Th17 cells are imprinted with gut tropism and migrate to the inflamed gut. When in the gut, Th17 cells of oral origin can be activated by translocated oral pathobionts and cause development of colitis, but they are not activated by gut-resident microbes. Thus, oral inflammation, such as periodontitis, exacerbates gut inflammation by supplying the gut with both colitogenic pathobionts and pathogenic T cells. |
| Volume | 182(2) |
| Pages | 447-462.e14 |
| Published | 2020-7-23 |
| DOI | 10.1016/j.cell.2020.05.048 |
| PII | S0092-8674(20)30681-4 |
| PMID | 32758418 |
| PMC | PMC7414097 |
| MeSH | Animals Colitis / microbiology Colitis / pathology* Colon / microbiology Colon / pathology Disease Models, Animal Enterobacter / isolation & purification Enterobacter / physiology* Female Gastrointestinal Microbiome* Inflammasomes / metabolism Interleukin-10 / deficiency Interleukin-10 / genetics Interleukin-1beta / metabolism Klebsiella / isolation & purification Klebsiella / physiology* Leukocytes, Mononuclear / cytology Leukocytes, Mononuclear / immunology Leukocytes, Mononuclear / metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Mouth / microbiology* Periodontitis / microbiology Periodontitis / pathology Th17 Cells / cytology Th17 Cells / immunology Th17 Cells / metabolism |
| IF | 38.637 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 328 |
| Altmetric score changes over past 6months | 3.7 |
| Resource | |
| Mice | RBRC05737 |