| RRC ID |
86806
|
| 著者 |
Iwata T, Niimura Y, Kobayashi C, Shirakawa D, Suzuki H, Enomoto T, Touhara K, Yoshihara Y, Hirota J.
|
| タイトル |
A long-range cis-regulatory element for class I odorant receptor genes.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Individual olfactory sensory neurons express a single odorant receptor gene from either class I genes residing in a single cluster on a single chromosome or class II genes spread over multiple clusters on multiple chromosomes. Here, we identify an enhancer element for mouse class I genes, the J element, that is conserved through mammalian species from the platypus to humans. The J element regulates most class I genes expression by exerting an effect over ~ 3 megabases within the whole cluster. Deletion of the trans J element increases the expression frequencies of class I genes from the intact J allele, indicating that the allelic exclusion of class I genes depends on the activity of the J element. Our data reveal a long-range cis-regulatory element that governs the singular class I gene expression and has been phylogenetically preserved to retain a single cluster organization of class I genes in mammals."Each olfactory sensory neuron expresses a single odorant receptor gene from either class I or class II genes. Here, the authors identify an enhancer for mouse class I genes, that is highly conserved, and regulates most class I genes expression by acting over ~ 3 megabases within the whole cluster."
|
| 巻・号 |
8(1)
|
| ページ |
885
|
| 公開日 |
2017-10-12
|
| DOI |
10.1038/s41467-017-00870-4
|
| PII |
10.1038/s41467-017-00870-4
|
| PMID |
29026079
|
| PMC |
PMC5638857
|
| MeSH |
Animals
Conserved Sequence
Enhancer Elements, Genetic*
Gene Expression Regulation
Mice
Multigene Family
Olfactory Receptor Neurons / metabolism*
Phylogeny
Receptors, Odorant / genetics*
|
| IF |
12.121
|
| リソース情報 |
| ゼブラフィッシュ |
UAS:GFP |
