論文 - 詳細
| RRC ID | 86806 |
|---|---|
| 著者 | Iwata T, Niimura Y, Kobayashi C, Shirakawa D, Suzuki H, Enomoto T, Touhara K, Yoshihara Y, Hirota J. |
| タイトル | A long-range cis-regulatory element for class I odorant receptor genes. |
| ジャーナル | Nat Commun |
| Abstract |
Individual olfactory sensory neurons express a single odorant receptor gene from either class I genes residing in a single cluster on a single chromosome or class II genes spread over multiple clusters on multiple chromosomes. Here, we identify an enhancer element for mouse class I genes, the J element, that is conserved through mammalian species from the platypus to humans. The J element regulates most class I genes expression by exerting an effect over ~ 3 megabases within the whole cluster. Deletion of the trans J element increases the expression frequencies of class I genes from the intact J allele, indicating that the allelic exclusion of class I genes depends on the activity of the J element. Our data reveal a long-range cis-regulatory element that governs the singular class I gene expression and has been phylogenetically preserved to retain a single cluster organization of class I genes in mammals."Each olfactory sensory neuron expresses a single odorant receptor gene from either class I or class II genes. Here, the authors identify an enhancer for mouse class I genes, that is highly conserved, and regulates most class I genes expression by acting over ~ 3 megabases within the whole cluster." |
| 巻・号 | 8(1) |
| ページ | 885 |
| 公開日 | 2017-10-12 |
| DOI | 10.1038/s41467-017-00870-4 |
| PII | 10.1038/s41467-017-00870-4 |
| PMID | 29026079 |
| PMC | PMC5638857 |
| MeSH | Animals Conserved Sequence Enhancer Elements, Genetic* Gene Expression Regulation Mice Multigene Family Olfactory Receptor Neurons / metabolism* Phylogeny Receptors, Odorant / genetics* |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | UAS:GFP |