論文 - 詳細
| RRC ID | 86821 |
|---|---|
| 著者 | Trsan T, Peng V, Krishna C, Ohara TE, Beatty WL, Sudan R, Kanai M, Krishnamoorthy P, Rodrigues PF, Fachi JL, Grajales-Reyes G, Jaeger N, Fitzpatrick JAJ, Cella M, Gilfillan S, Nakata T, Jaiswal A, Stappenbeck TS, Daly MJ, Xavier RJ, Colonna M. |
| タイトル | The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells. |
| ジャーナル | Dev Cell |
| Abstract |
Recent advances in human genetics have shed light on the genetic factors contributing to inflammatory diseases, particularly Crohn's disease (CD), a prominent form of inflammatory bowel disease. Certain risk genes associated with CD directly influence cytokine biology and cell-specific communication networks. Current CD therapies primarily rely on anti-inflammatory drugs, which are inconsistently effective and lack strategies for promoting epithelial restoration and mucosal balance. To understand CD's underlying mechanisms, we investigated the link between CD and the FGFR1OP gene, which encodes a centrosome protein. FGFR1OP deletion in mouse intestinal epithelial cells disrupted crypt architecture, resulting in crypt loss, inflammation, and fatality. FGFR1OP insufficiency hindered epithelial resilience during colitis. FGFR1OP was crucial for preserving non-muscle myosin II activity, ensuring the integrity of the actomyosin cytoskeleton and crypt cell adhesion. This role of FGFR1OP suggests that its deficiency in genetically predisposed individuals may reduce epithelial renewal capacity, heightening susceptibility to inflammation and disease. |
| 巻・号 | 59(18) |
| ページ | 2460-2476.e10 |
| 公開日 | 2024-9-23 |
| DOI | 10.1016/j.devcel.2024.06.001 |
| PII | S1534-5807(24)00379-4 |
| PMID | 38942017 |
| PMC | PMC11421975 |
| MeSH | Actomyosin / metabolism Animals Cell Adhesion Centrosome / metabolism Colitis / chemically induced Colitis / genetics Colitis / metabolism Colitis / pathology Crohn Disease / genetics Crohn Disease / metabolism Crohn Disease / pathology Epithelial Cells* / metabolism Humans Inflammation / genetics Inflammation / metabolism Inflammation / pathology Intestinal Mucosa* / metabolism Mice Mice, Inbred C57BL Myosin Type II* / genetics Myosin Type II* / metabolism |
| IF | 10.092 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 27 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC01834 |