論文 - 詳細
| RRC ID | 86823 |
|---|---|
| 著者 | Ogishi M, Kitaoka K, Good-Jacobson KL, Rinchai D, Zhang B, Wang J, Gies V, Rao G, Nguyen T, Avery DT, Khan T, Smithmyer ME, Mackie J, Yang R, Arias AA, Asano T, Ponsin K, Chaldebas M, Zhang P, Peel JN, Bohlen J, Lévy R, Pelham SJ, Lei WT, Han JE, Fagniez I, Chrabieh M, Laine C, Langlais D, Gruber C, Al Ali F, Rahman M, Aytekin C, Benson B, Dufort MJ, Domingo-Vila C, Moriya K, Shlomchik M, Uzel G, Gray PE, Suan D, Preece K, Chua I, Okada S, Chikuma S, Kiyonari H, Tree TI, Bogunovic D, Gros P, Marr N, Speake C, Oram RA, Béziat V, Bustamante J, Abel L, Boisson B, Korganow AS, Ma CS, Johnson MB, Chamoto K, Boisson-Dupuis S, Honjo T, Casanova JL, Tangye SG. |
| タイトル | Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling. |
| ジャーナル | Immunity |
| Abstract |
T follicular helper (Tfh) cells abundantly express the immunoreceptor programmed cell death protein 1 (PD-1), and the impact of PD-1 deficiency on antibody (Ab)-mediated immunity in mice is associated with compromised Tfh cell functions. Here, we revisited the role of the PD-1-PD-L1 axis on Ab-mediated immunity. Individuals with inherited PD-1 or PD-L1 deficiency had fewer memory B cells and impaired Ab responses, similar to Pdcd1-/- and Cd274-/-Pdcd1lg2-/- mice. PD-1, PD-L1, or both could be detected on the surface of human naive B cells following in vitro activation. PD-1- or PD-L1-deficient B cells had reduced expression of the transcriptional regulator c-Myc and c-Myc-target genes in vivo, and PD-1 deficiency or neutralization of PD-1 or PD-L1 impeded c-Myc expression and Ab production in human B cells isolated in vitro. Furthermore, B cell-specific deletion of Pdcd1 prevented the physiological accumulation of memory B cells in mice. Thus, PD-1 shapes optimal B cell memory and Ab-mediated immunity through B cell-intrinsic and B cell-extrinsic mechanisms, suggesting that B cell dysregulation contributes to infectious and autoimmune complications following anti-PD-1-PD-L1 immunotherapy. |
| 巻・号 | 57(12) |
| ページ | 2790-2807.e15 |
| 公開日 | 2024-12-10 |
| DOI | 10.1016/j.immuni.2024.10.014 |
| PII | S1074-7613(24)00495-3 |
| PMID | 39603236 |
| PMC | PMC11634639 |
| MeSH | Animals Antibody Formation / genetics Antibody Formation / immunology B-Lymphocytes / immunology B7-H1 Antigen* / genetics B7-H1 Antigen* / immunology B7-H1 Antigen* / metabolism Cell Differentiation / immunology Humans Lymphocyte Activation / immunology Memory B Cells* / immunology Mice Mice, Inbred C57BL Mice, Knockout* Programmed Cell Death 1 Ligand 2 Protein / genetics Programmed Cell Death 1 Ligand 2 Protein / immunology Programmed Cell Death 1 Ligand 2 Protein / metabolism Programmed Cell Death 1 Receptor* / immunology Programmed Cell Death 1 Receptor* / metabolism Proto-Oncogene Proteins c-myc* / genetics Proto-Oncogene Proteins c-myc* / immunology Proto-Oncogene Proteins c-myc* / metabolism Signal Transduction* / immunology T Follicular Helper Cells / immunology |
| IF | 22.553 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 105 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02142 |