論文 - 詳細
| RRC ID | 86824 |
|---|---|
| 著者 | Pokhrel S, Dileepan G, Leonard MR, Warren RT, Salem M, Yacapraro AJ, Gong Q, Jones DM, Tuazon JA, Read KA, Yount JS, Xin G, Forero A, Ghoneim HE, Collins PL, Hemann EA, Oestreich KJ. |
| タイトル | Aiolos restricts the generation of antigen-inexperienced, virtual memory CD8+ T cells in mice. |
| ジャーナル | Nat Commun |
| Abstract |
CD8+ virtual memory T (TVM) cells rapidly respond to infection via antigen-independent bystander effector functions. While it is recognized that TVM cells arise independently of foreign antigen encounter, the mechanisms governing their development are not fully understood. Here, we identify the Ikaros transcription factor Aiolos as a negative regulator of TVM cell programming. We observe enhanced frequencies and numbers of TVM in the spleen, liver, and blood of unchallenged Aiolos-deficient (Ikzf3-/-) mice and in the lungs 1-day post-infection with influenza A virus (IAV). Furthermore, Ikzf3-/- TVM cells produce elevated IFN-γ and granzyme B in response to cytokine stimulation. Importantly, Aiolos-deficient mice control IAV more rapidly and exhibit reduced morbidity, indicating enhanced TVM cell functionality. Mechanistically, Aiolos represses the expression of the transcription factor Eomes and the IL-15R subunit CD122, known positive regulators of TVM gene program. Collectively, these findings establish Aiolos as a molecular repressor of TVM programming and responses. |
| 巻・号 | 17(1) |
| ページ | 839 |
| 公開日 | 2025-12-14 |
| DOI | 10.1038/s41467-025-67540-8 |
| PII | 10.1038/s41467-025-67540-8 |
| PMID | 41392082 |
| PMC | PMC12827986 |
| MeSH | Animals CD8-Positive T-Lymphocytes* / immunology CD8-Positive T-Lymphocytes* / metabolism Granzymes / immunology Granzymes / metabolism Ikaros Transcription Factor* / genetics Ikaros Transcription Factor* / immunology Ikaros Transcription Factor* / metabolism Immunologic Memory* Influenza A virus / immunology Interferon-gamma / immunology Interferon-gamma / metabolism Interleukin-2 Receptor beta Subunit / genetics Interleukin-2 Receptor beta Subunit / immunology Interleukin-2 Receptor beta Subunit / metabolism Lung / immunology Lung / virology Memory T Cells* / immunology Mice Mice, Inbred C57BL Mice, Knockout Orthomyxoviridae Infections / immunology T-Box Domain Proteins / genetics T-Box Domain Proteins / immunology T-Box Domain Proteins / metabolism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC05582 |