| RRC ID |
86862
|
| Author |
Maega S, Uegaki R, Ono M, Bito T, Iwasaki T, Kawano T.
|
| Title |
The neuropeptide receptor-22, expressed in the intestine, regulates larval development by modulating the production and secretion of insulin-like peptide INS-35 in Caenorhabditis elegans.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
FMRFamide peptides are highly conserved across invertebrates and are involved in various physiological responses. In nematodes, FMRFamide-like peptides (FLPs) and their receptor candidates, the neuropeptide receptors (NPRs), play a significant role in regulating physiological processes. In this study, we further investigated the molecular genetics of the npr-22 gene to determine its role in larval development in the free-living soil nematode model species, Caenorhabditis elegans. Our findings revealed the following: (1) NPR-22 inhibits larval development by interacting with insulin-like signaling pathway, as well as transforming growth factor-β (TGF-β)-like signaling pathway. This interaction leads to dauer diapause, a form of developmental arrest; (2) NPR-22 is expressed in the intestine and modulates the dauer diapause by regulating the production and secretion of insulin-like peptide 35 (INS-35), a predominant ligand of the sole insulin receptor-like protein, DAF-2. This study highlights the finding that a G protein-coupled receptor, expressed in various tissues, regulates the expression of distinct growth hormones involved in C. elegans development.
|
| Volume |
808
|
| Pages |
153401
|
| Published |
2026-2-4
|
| DOI |
10.1016/j.bbrc.2026.153401
|
| PII |
S0006-291X(26)00165-8
|
| PMID |
41702186
|
| Resource |
| C.elegans |
tm13562 |
