論文 - 詳細
| RRC ID | 86867 |
|---|---|
| 著者 | Kim JG, Cron GO, Kim M, Hossain A, Lee JH. |
| タイトル | Empathy and prosocial behavior powered by orexin-driven theta oscillations. |
| ジャーナル | Science |
| Abstract |
Empathy measured through observational fear in rodents has been associated with increased theta oscillations in the anterior cingulate cortex (ACC). However, upstream circuit mechanisms modulating these oscillations and the extent of the oscillations' role in empathy-related behaviors remain elusive. We found that in mice, ACC theta oscillations are involved in empathy-driven prosocial allogrooming. Moreover, orexinergic neurons are selectively activated in the ACC during observational fear and prosocial allogrooming, but only when the animals had prior fear experience. Real-time, gaze-dependent optogenetic inhibition of lateral hypothalamic orexinergic inputs to ACC suppressed theta power and reduced both behaviors. These findings show that hypothalamic orexinergic inputs drive ACC theta oscillations to modulate observational fear and prosocial behaviors, providing circuit-level insight into how affective empathy translates into prosocial action. |
| 巻・号 | 391(6787) |
| ページ | 800-806 |
| 公開日 | 2026-2-19 |
| DOI | 10.1126/science.aea7140 |
| PMID | 41712718 |
| MeSH | Animals Empathy* / physiology Fear / physiology Gyrus Cinguli* / physiology Hypothalamic Area, Lateral / physiology Male Mice Mice, Inbred C57BL Neurons / physiology Optogenetics Orexins* / metabolism Orexins* / physiology Social Behavior* Theta Rhythm* / physiology |
| IF | 41.846 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 50 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 48.2 |
| リソース情報 | |
| 実験動物マウス | RBRC11555 |