Reference - Detail
| RRC ID | 86883 |
|---|---|
| Author | Tanabe H, Maeda S, Sano E, Sakai N, Endoh-Yamagami S, Okano H. |
| Title | Tau aggregation induces cell death in iPSC-derived neurons. |
| Journal | Aging Brain |
| Abstract |
Abnormal accumulation of tau proteins in the brain is a hallmark of neurodegenerative diseases such as Alzheimer's disease and is closely linked with neuronal cell death. Tau accumulation is a prominent therapeutic target for Alzheimer's disease, since tau accumulation correlates well with the disease progression, and tau-targeting drugs hold potentials to halt the disease progression. Given the differential response of human and mouse neuronal cells, there is a critical need for a human cellular platform to quickly screen for tau-related neurodegenerative disease therapeutics. However, inducing rapid, tau-dependent neuronal cell death in human models remains challenging. In this study, we established a human cellular model capable of inducing tau aggregation-dependent neuronal cell death within two weeks via tau overexpression. Additionally, we demonstrated the neuroprotective efficacy of known tau-targeting compounds within this system. These findings suggest that our cellular model recapitulates the molecular pathogenesis of tau-induced neurodegeneration and could serve as a valuable platform for drug screening in tauopathies. |
| Volume | 7 |
| Pages | 100136 |
| Published | 2025-1-1 |
| DOI | 10.1016/j.nbas.2025.100136 |
| PII | S2589-9589(25)00002-7 |
| PMID | 40276591 |
| PMC | PMC12018045 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | News |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | CSII-EF-MCS (RDB04378) |