論文 - 詳細
| RRC ID | 86908 |
|---|---|
| 著者 | Sui L, Fischer-Friedrich E, Dahmann C. |
| タイトル | Extracellular matrix restrains cell-cycle progression by nuclear exclusion of Yorkie in Drosophila. |
| ジャーナル | Curr Biol |
| Abstract |
Tissues and organs grow to a characteristic final size during animal development. A hallmark of tissues reaching their final size is the cessation of cell-cycle progression. However, the mechanisms by which cell-cycle progression is halted in tissues reaching their final size remain largely unknown. Here, we show that the extracellular matrix (ECM) is necessary and sufficient to halt cell-cycle progression at G2 phase in Drosophila late-larval-stage wing discs reaching their final size. Depleting ECM in late-larval-stage wing discs leads to nuclear accumulation of the co-transcriptional activator Yorkie (YAP and TAZ in mammals) and to a Yorkie-dependent release of cells from G2-phase arrest. Conversely, increasing ECM thickness induces precocious G2-phase accumulation, which is overcome by expression of an activated form of Yorkie. Furthermore, we show that programmed ECM degradation is necessary for the normal resumption of cell-cycle progression during later pupal stages and for proper adult wing size. Our work identifies a critical role for ECM in restraining cell-cycle progression in tissues reaching their final size and reveals ECM-mediated nuclear exclusion of Yorkie as a key mechanism. |
| 巻・号 | 36(2) |
| ページ | 474-491.e5 |
| 公開日 | 2026-1-19 |
| DOI | 10.1016/j.cub.2025.11.079 |
| PII | S0960-9822(25)01620-3 |
| PMID | 41512852 |
| MeSH | Animals Cell Cycle* / physiology Cell Nucleus / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster* / genetics Drosophila melanogaster* / growth & development Drosophila melanogaster* / physiology Extracellular Matrix* / metabolism Extracellular Matrix* / physiology Larva / growth & development Nuclear Proteins* / genetics Nuclear Proteins* / metabolism Pupa / growth & development Trans-Activators* / genetics Trans-Activators* / metabolism Wings, Animal / growth & development YAP-Signaling Proteins |
| IF | 9.601 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |