| RRC ID |
86977
|
| Author |
Takeo M, Toyoshima KE, Fujimoto R, Iga T, Takase M, Ogawa M, Tsuji T.
|
| Title |
Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair.
|
| Journal |
Nat Commun
|
| Abstract |
Biological rhythms are involved in almost all types of biological processes, not only physiological processes but also morphogenesis. Currently, how periodic morphological patterns of tissues/organs in multicellular organisms form is not fully understood. Here, using mouse zigzag hair, which has 3 bends, we found that a change in the combination of hair progenitors and their micro-niche and subsequent bend formation occur every three days. Chimeric loss-of-function and gain-of-function of Ptn and Aff3, which are upregulated immediately before bend formation, resulted in defects in the downward movement of the micro-niche and the rhythm of bend formation in an in vivo hair reconstitution assay. Our study demonstrates the periodic change in the combination between progenitors and micro-niche, which is vital for the unique infradian rhythm.
|
| Volume |
14(1)
|
| Pages |
4478
|
| Published |
2023-8-4
|
| DOI |
10.1038/s41467-023-39605-z
|
| PII |
10.1038/s41467-023-39605-z
|
| PMID |
37542032
|
| PMC |
PMC10403492
|
| MeSH |
Animals
Hair
Hair Follicle
Infradian Rhythm*
Mice
Periodicity
|
| Resource |
| Mice |
RBRC02707 |
