論文 - 詳細
| RRC ID | 86982 |
|---|---|
| 著者 | Molostvov G, Gachechiladze M, Shaaban AM, Hayward S, Dean I, Dias IHK, Badr N, Danial I, Mohammed F, Novitskaya V, Paniushkina L, Speirs V, Hanby A, Nazarenko I, Withers DR, van Laere S, Long HM, Berditchevski F. |
| タイトル | Tspan6 stimulates the chemoattractive potential of breast cancer cells for B cells in an EV- and LXR-dependent manner. |
| ジャーナル | Cell Rep |
| Abstract |
The immune microenvironment in breast cancer (BCa) is controlled by a complex network of communication between various cell types. Here, we find that recruitment of B lymphocytes to BCa tissues is controlled via mechanisms associated with cancer cell-derived extracellular vesicles (CCD-EVs). Gene expression profiling identifies the Liver X receptor (LXR)-dependent transcriptional network as a key pathway that controls both CCD-EVs-induced migration of B cells and accumulation of B cells in BCa tissues. The increased accumulation oxysterol ligands for LXR (i.e., 25-hydroxycholesterol and 27-hydroxycholesterol) in CCD-EVs is regulated by the tetraspanin 6 (Tspan6). Tspan6 stimulates the chemoattractive potential of BCa cells for B cells in an EV- and LXR-dependent manner. These results demonstrate that tetraspanins control intercellular trafficking of oxysterols via CCD-EVs. Furthermore, tetraspanin-dependent changes in the oxysterol composition of CCD-EVs and the LXR signaling axis play a key role in specific changes in the tumor immune microenvironment. |
| 巻・号 | 42(3) |
| ページ | 112207 |
| 公開日 | 2023-3-28 |
| DOI | 10.1016/j.celrep.2023.112207 |
| PII | S2211-1247(23)00218-8 |
| PMID | 36867531 |
| MeSH | B-Lymphocytes / metabolism Breast Neoplasms* / genetics Female Humans Liver X Receptors / metabolism Oxysterols* / pharmacology Tetraspanins Tumor Microenvironment |
| リソース情報 | |
| 実験動物マウス | RBRC09257 |