論文 - 詳細
| RRC ID | 86983 |
|---|---|
| 著者 | Grootveld AK, Kyaw W, Panova V, Lau AWY, Ashwin E, Seuzaret G, Dhenni R, Bhattacharyya ND, Khoo WH, Biro M, Mitra T, Meyer-Hermann M, Bertolino P, Tanaka M, Hume DA, Croucher PI, Brink R, Nguyen A, Bannard O, Phan TG. |
| タイトル | Apoptotic cell fragments locally activate tingible body macrophages in the germinal center. |
| ジャーナル | Cell |
| Abstract |
Germinal centers (GCs) that form within lymphoid follicles during antibody responses are sites of massive cell death. Tingible body macrophages (TBMs) are tasked with apoptotic cell clearance to prevent secondary necrosis and autoimmune activation by intracellular self antigens. We show by multiple redundant and complementary methods that TBMs derive from a lymph node-resident, CD169-lineage, CSF1R-blockade-resistant precursor that is prepositioned in the follicle. Non-migratory TBMs use cytoplasmic processes to chase and capture migrating dead cell fragments using a "lazy" search strategy. Follicular macrophages activated by the presence of nearby apoptotic cells can mature into TBMs in the absence of GCs. Single-cell transcriptomics identified a TBM cell cluster in immunized lymph nodes which upregulated genes involved in apoptotic cell clearance. Thus, apoptotic B cells in early GCs trigger activation and maturation of follicular macrophages into classical TBMs to clear apoptotic debris and prevent antibody-mediated autoimmune diseases. |
| 巻・号 | 186(6) |
| ページ | 1144-1161.e18 |
| 公開日 | 2023-3-16 |
| DOI | 10.1016/j.cell.2023.02.004 |
| PII | S0092-8674(23)00106-X |
| PMID | 36868219 |
| PMC | PMC7614509 |
| MeSH | Apoptosis B-Lymphocytes Germinal Center* Lymph Nodes* / cytology Macrophages* / cytology Macrophages* / metabolism |
| IF | 38.637 |
| リソース情報 | |
| 実験動物マウス | RBRC06239 |