論文 - 詳細
| RRC ID | 86996 |
|---|---|
| 著者 | Miyamoto K, Sujino T, Harada Y, Ashida H, Yoshimatsu Y, Yonemoto Y, Nemoto Y, Tomura M, Melhem H, Niess JH, Suzuki T, Suzuki T, Suzuki S, Koda Y, Okamoto R, Mikami Y, Teratani T, Tanaka KF, Yoshimura A, Sato T, Kanai T. |
| タイトル | The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis. |
| ジャーナル | Cell Rep |
| Abstract |
The intricate interplay between gut microbes and the onset of experimental autoimmune encephalomyelitis (EAE) remains poorly understood. Here, we uncover remarkable similarities between CD4+ T cells in the spinal cord and their counterparts in the small intestine. Furthermore, we unveil a synergistic relationship between the microbiota, particularly enriched with the tryptophan metabolism gene EC:1.13.11.11, and intestinal cells. This symbiotic collaboration results in the biosynthesis of kynurenic acid (KYNA), which modulates the recruitment and aggregation of GPR35-positive macrophages. Subsequently, a robust T helper 17 (Th17) immune response is activated, ultimately triggering the onset of EAE. Conversely, modulating the KYNA-mediated GPR35 signaling in Cx3cr1+ macrophages leads to a remarkable amelioration of EAE. These findings shed light on the crucial role of microbial-derived tryptophan metabolites in regulating immune responses within extraintestinal tissues. |
| 巻・号 | 42(8) |
| ページ | 113005 |
| 公開日 | 2023-8-29 |
| DOI | 10.1016/j.celrep.2023.113005 |
| PII | S2211-1247(23)01016-1 |
| PMID | 37590143 |
| MeSH | Animals Encephalitis* Encephalomyelitis, Autoimmune, Experimental* Gastrointestinal Microbiome* Kynurenic Acid Macrophages Tryptophan |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 57 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 実験動物マウス | RBRC05737 |