論文 - 詳細
| RRC ID | 86998 |
|---|---|
| 著者 | Li Z, Tuong ZK, Dean I, Willis C, Gaspal F, Fiancette R, Idris S, Kennedy B, Ferdinand JR, Peñalver A, Cabantous M, Murtuza Baker S, Fry JW, Carlesso G, Hammond SA, Dovedi SJ, Hepworth MR, Clatworthy MR, Withers DR. |
| タイトル | In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue. |
| ジャーナル | J Exp Med |
| Abstract |
Improving the efficacy of immune checkpoint therapies will require a better understanding of how immune cells are recruited and sustained in tumors. Here, we used the photoconversion of the tumor immune cell compartment to identify newly entering lymphocytes, determine how they change over time, and investigate their egress from the tumor. Combining single-cell transcriptomics and flow cytometry, we found that while a diverse mix of CD8 T cell subsets enter the tumor, all CD8 T cells retained within this environment for more than 72 h developed an exhausted phenotype, revealing the rapid establishment of this program. Rather than forming tumor-resident populations, non-effector subsets, which express TCF-1 and include memory and stem-like cells, were continuously recruited into the tumor, but this recruitment was balanced by concurrent egress to the tumor-draining lymph node. Thus, the TCF-1+ CD8 T cell niche in tumors is highly dynamic, with the circulation of cells between the tumor and peripheral lymphoid tissue to bridge systemic and intratumoral responses. |
| 巻・号 | 219(6) |
| 公開日 | 2022-6-6 |
| DOI | 10.1084/jem.20210749 |
| PII | 213181 |
| PMID | 35472220 |
| PMC | PMC9048291 |
| MeSH | CD8-Positive T-Lymphocytes* Humans Immunotherapy Lymphoid Tissue Neoplasms* T-Lymphocyte Subsets |
| IF | 11.743 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 68 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC09257 |