論文 - 詳細
| RRC ID | 87012 |
|---|---|
| 著者 | Imai R, Mizuno K, Omiya Y, Mizoguchi K, Maejima Y, Shimomura K. |
| タイトル | The effects of ninjin'yoeito on the electrophysiological properties of dopamine neurons in the ventral tegmental area/substantia nigra pars compacta and medium spiny neurons in the nucleus accumbens. |
| ジャーナル | Aging (Albany NY) |
| Abstract |
The ventral tegmental area (VTA), substantia nigra pars compacta (SNpc) and nucleus accumbens (NAc) are involved in the regulation of appetite and motivational behaviors. A traditional Japanese (Kampo) medicine, ninjin'yoeito (NYT), has been reported to improve decreased motivation and anorexia in patients with Alzheimer's disease and apathy-like model mice. Thus, NYT may affect the activities of neurons in the VTA, SNpc and NAc. However, little is known about the underlying mechanisms of NYT. Here, we investigated the effects of NYT on the electrophysiological properties of dopaminergic neurons in the VTA and SNpc, as well as on those of medium spiny neurons (MSNs) in the NAc (core and shell subregions), by applying the patch-clamp technique in the brain slices. NYT reduced the resting membrane potential of VTA and SNpc dopaminergic neurons. In contrast, NYT increased the firing frequency of NAc MSNs accompanied by shortened first spike latency and interspike interval. Furthermore, NYT attenuated the inward rectification and sustained outward currents. In conclusion, NYT may directly influence the excitability of dopaminergic neurons in the VTA and SNpc, as well as MSNs in the NAc (core and shell). NYT may modulate dopamine signals in appetite and motivational behaviors. |
| 巻・号 | 14(11) |
| ページ | 4634-4652 |
| 公開日 | 2022-6-3 |
| DOI | 10.18632/aging.204109 |
| PII | 204109 |
| PMID | 35660668 |
| PMC | PMC9217710 |
| MeSH | Animals Dopaminergic Neurons* Drugs, Chinese Herbal Humans Mice Nucleus Accumbens / physiology Pars Compacta Ventral Tegmental Area* |
| IF | 4.831 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02095 |