論文 - 詳細
| RRC ID | 87146 |
|---|---|
| 著者 | Dey P, Singhania A, Kunnumakkara AB, Ghosh S, Bandyopadhyay A. |
| タイトル | Mechanical Dialogues of Life and Death: How External Molecules Entry Triggers a Chromatin-Cytoskeleton Morphogenetic Duel in Cancer Cells. |
| ジャーナル | Adv Biol (Weinh) |
| Abstract |
The next-generation anti-cancer therapeutics must disrupt intracellular mechanics, efficiently eradicating cancer cells, rather than simply intoxicating them. We evaluate the mechanism of action of PCMS, a PAMAM-based supramolecule that eradicates cancer cells by reorganizing their internal mechanics rather than their genes. Once internalized, PCMS self-assembles into a perinuclear ring that severs nucleus-cytoskeleton communication. We observed PCMS's dual-intelligent mechanisms of action: Cytoskeletal rescue, where actin-microtubule filaments move towards the PCMS ring, treating it as a surrogate plasma membrane, attempting to restore vesicular trafficking; Nuclear counter-expansion, where chromatin-lamina condensates undergo stepwise viscoelastic transitions that push the nuclear envelope outward to reestablish membrane contact. These contradictory forces amplify mechanical stress, driving super-critical strain and nuclear lysis without broad transcriptional modulations. By geometry alone, PCMS collapses the actin-microtubule-nucleus continuum and turns the cell's adaptive machinery into its own executioner. The discovery that life and death decisions can be reprogrammed through spatial conflict establishes a paradigm of mechanical deception, inaugurating a new class of cellular adaptive feedback-targeted mechanotherapeutics that overcome resistance by exploiting the cell's own morphogenetic logic. |
| 巻・号 | 10(2) |
| ページ | e00716 |
| 公開日 | 2026-2-1 |
| DOI | 10.1002/adbi.202500716 |
| PMID | 41715943 |
| MeSH | Cell Line, Tumor Chromatin* / metabolism Cytoskeleton* / metabolism Humans Neoplasms* / metabolism Neoplasms* / pathology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 27 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 15.3 |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB3677) |