Reference - Detail
| RRC ID | 87155 |
|---|---|
| Author | Ohi Y, Hada K, Murata Y, Kodama D, Wakiya Y. |
| Title | Bidirectional effects of orexin receptor antagonists on long-term potentiation in the hippocampus of wild type and Alzheimer's disease model mice. |
| Journal | J Pharmacol Sci |
| Abstract |
The orexinergic system is dysregulated in patients with Alzheimer's disease (AD). In the present study, we evaluated the effects of chronic administration of dual orexin receptor antagonists, suvorexant (Suv) and lemborexant (Lem), on long-term potentiation (LTP) in the hippocampal CA1 region of wild-type (WT) and APPNL-G-F knock-in (APP-KI) mice. LTP was enhanced in APP-KI mice compared with WT mice. Chronic administration of Suv and Lem further potentiated LTP in WT mice. In contrast, in APP-KI mice, Suv moderately and Lem markedly reduced LTP. These findings suggest that orexin receptor antagonists bidirectionally modulate LTP in WT and AD model mice. |
| Volume | 160(1) |
| Pages | 37-40 |
| Published | 2026-1-1 |
| DOI | 10.1016/j.jphs.2025.11.003 |
| PII | S1347-8613(25)00107-0 |
| PMID | 41390193 |
| MeSH | Alzheimer Disease* / drug therapy Alzheimer Disease* / physiopathology Animals Azepines* / administration & dosage Azepines* / pharmacology CA1 Region, Hippocampal* / drug effects Disease Models, Animal Hippocampus* / drug effects Long-Term Potentiation* / drug effects Male Mice Mice, Inbred C57BL Mice, Transgenic Orexin Receptor Antagonists* / administration & dosage Orexin Receptor Antagonists* / pharmacology Pyridines* / pharmacology Triazoles* / administration & dosage Triazoles* / pharmacology |
| IF | 2.835 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC06344 |