| RRC ID |
87155
|
| Author |
Ohi Y, Hada K, Murata Y, Kodama D, Wakiya Y.
|
| Title |
Bidirectional effects of orexin receptor antagonists on long-term potentiation in the hippocampus of wild type and Alzheimer's disease model mice.
|
| Journal |
J Pharmacol Sci
|
| Abstract |
The orexinergic system is dysregulated in patients with Alzheimer's disease (AD). In the present study, we evaluated the effects of chronic administration of dual orexin receptor antagonists, suvorexant (Suv) and lemborexant (Lem), on long-term potentiation (LTP) in the hippocampal CA1 region of wild-type (WT) and APPNL-G-F knock-in (APP-KI) mice. LTP was enhanced in APP-KI mice compared with WT mice. Chronic administration of Suv and Lem further potentiated LTP in WT mice. In contrast, in APP-KI mice, Suv moderately and Lem markedly reduced LTP. These findings suggest that orexin receptor antagonists bidirectionally modulate LTP in WT and AD model mice.
|
| Volume |
160(1)
|
| Pages |
37-40
|
| Published |
2026-1-1
|
| DOI |
10.1016/j.jphs.2025.11.003
|
| PII |
S1347-8613(25)00107-0
|
| PMID |
41390193
|
| MeSH |
Alzheimer Disease* / drug therapy
Alzheimer Disease* / physiopathology
Animals
Azepines* / administration & dosage
Azepines* / pharmacology
CA1 Region, Hippocampal* / drug effects
Disease Models, Animal
Hippocampus* / drug effects
Long-Term Potentiation* / drug effects
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Orexin Receptor Antagonists* / administration & dosage
Orexin Receptor Antagonists* / pharmacology
Pyridines* / pharmacology
Triazoles* / administration & dosage
Triazoles* / pharmacology
|
| Resource |
| Mice |
RBRC06344 |
