Reference - Detail
| RRC ID | 87168 |
|---|---|
| Author | Lingamallu SM, Deshpande A, Joy N, Ganeshan K, Ray N, Ladher RK, Taketo MM, Lafkas D, Guha A. |
| Title | Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition. |
| Journal | Cell Rep |
| Abstract |
Lower airway club cells (CCs) serve the dual roles of a secretory cell and a stem cell. Here, we probe how the CC fate is regulated. We find that, in response to acute perturbation of Notch signaling, CCs adopt distinct fates. Although the vast majority transdifferentiate into multiciliated cells, a "variant" subpopulation (v-CCs), juxtaposed to neuroepithelial bodies (NEBs; 5%-10%) and located at bronchioalveolar duct junctions (>80%), does not. Instead, v-CCs transition into lineage-ambiguous states but can revert to a CC fate upon restoration of Notch signaling and repopulate the airways with CCs and multiciliated cells. The v-CC response to Notch inhibition is dependent on localized activation of β-catenin in v-CCs. We propose that the CC fate is stabilized by canonical Notch signaling, that airways are susceptible to perturbations to this pathway, and that NEBs/terminal bronchioles comprise niches that modulate CC plasticity via β-catenin activation to facilitate airway repair post Notch inhibition. |
| Volume | 43(9) |
| Pages | 114654 |
| Published | 2024-9-24 |
| DOI | 10.1016/j.celrep.2024.114654 |
| PII | S2211-1247(24)01005-2 |
| PMID | 39182223 |
| MeSH | Animals Bronchioles* / cytology Bronchioles* / metabolism Mice Mice, Inbred C57BL Neuroepithelial Bodies* / metabolism Receptors, Notch* / metabolism Signal Transduction* beta Catenin* / metabolism |
| IF | 8.109 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC01071 |