Reference - Detail
| RRC ID | 87169 |
|---|---|
| Author | Pu W, Zhu H, Zhang M, Pikiolek M, Ercan C, Li J, Huang X, Han X, Zhang Z, Lv Z, Li Y, Liu K, He L, Liu X, Heim MH, Terracciano LM, Tchorz JS, Zhou B. |
| Title | Bipotent transitional liver progenitor cells contribute to liver regeneration. |
| Journal | Nat Genet |
| Abstract |
Following severe liver injury, when hepatocyte-mediated regeneration is impaired, biliary epithelial cells (BECs) can transdifferentiate into functional hepatocytes. However, the subset of BECs with such facultative tissue stem cell potential, as well as the mechanisms enabling transdifferentiation, remains elusive. Here we identify a transitional liver progenitor cell (TLPC), which originates from BECs and differentiates into hepatocytes during regeneration from severe liver injury. By applying a dual genetic lineage tracing approach, we specifically labeled TLPCs and found that they are bipotent, as they either differentiate into hepatocytes or re-adopt BEC fate. Mechanistically, Notch and Wnt/β-catenin signaling orchestrate BEC-to-TLPC and TLPC-to-hepatocyte conversions, respectively. Together, our study provides functional and mechanistic insights into transdifferentiation-assisted liver regeneration. |
| Volume | 55(4) |
| Pages | 651-664 |
| Published | 2023-4-1 |
| DOI | 10.1038/s41588-023-01335-9 |
| PII | 10.1038/s41588-023-01335-9 |
| PMID | 36914834 |
| PMC | PMC10101857 |
| MeSH | Cell Differentiation / genetics Cell Proliferation / genetics Epithelial Cells Hepatocytes Liver* Liver Regeneration* Stem Cells |
| IF | 27.605 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 26 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC01071 |