論文 - 詳細
| RRC ID | 87174 |
|---|---|
| 著者 | Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernández-Klett F, Yamasaki A, Frosch M, Fliegauf M, Bosch LFP, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch KP, Lämmermann T, Priller J, Kierdorf K, Prinz M. |
| タイトル | Specification of CNS macrophage subsets occurs postnatally in defined niches. |
| ジャーナル | Nature |
| Abstract |
All tissue-resident macrophages of the central nervous system (CNS)-including parenchymal microglia, as well as CNS-associated macrophages (CAMs1) such as meningeal and perivascular macrophages2-7-are part of the CNS endogenous innate immune system that acts as the first line of defence during infections or trauma2,8-10. It has been suggested that microglia and all subsets of CAMs are derived from prenatal cellular sources in the yolk sac that were defined as early erythromyeloid progenitors11-15. However, the precise ontogenetic relationships, the underlying transcriptional programs and the molecular signals that drive the development of distinct CAM subsets in situ are poorly understood. Here we show, using fate-mapping systems, single-cell profiling and cell-specific mutants, that only meningeal macrophages and microglia share a common prenatal progenitor. By contrast, perivascular macrophages originate from perinatal meningeal macrophages only after birth in an integrin-dependent manner. The establishment of perivascular macrophages critically requires the presence of arterial vascular smooth muscle cells. Together, our data reveal a precisely timed process in distinct anatomical niches for the establishment of macrophage subsets in the CNS. |
| 巻・号 | 604(7907) |
| ページ | 740-748 |
| 公開日 | 2022-4-1 |
| DOI | 10.1038/s41586-022-04596-2 |
| PII | 10.1038/s41586-022-04596-2 |
| PMID | 35444273 |
| MeSH | Cell Lineage* Central Nervous System* / immunology Female Humans Immunity, Innate Macrophages* / cytology Microglia Pregnancy Yolk Sac |
| IF | 42.779 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 167 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 6.5 |
| リソース情報 | |
| 実験動物マウス | RBRC01071 |