| RRC ID |
87199
|
| Author |
Zhou H, Moriyasu D, Hsiao SW, Yamaguchi Y, Azuma M, Koshimizu TA, Itoi K, Sakimura K, Schwartz WJ, Okamura H, Hasegawa E, Doi M.
|
| Title |
Heterogeneity between VIP and GRP neurons underlies AVP receptor signaling in the mouse suprachiasmatic nucleus.
|
| Journal |
Commun Biol
|
| Abstract |
Understanding the network topology of a cluster of diverse neurons acting in concert requires a detailed expression map of ligand-receptor pairs involved in cell-cell communication. The neuropeptide arginine vasopressin (AVP) and signaling mediated by its cognate receptor V1a have been implicated in dorsal-to-ventral regional communication in the suprachiasmatic nucleus (SCN), a cluster of neurons that acts in concert to generate daily rhythms in behavior and physiology. Here, we show that among vasoactive intestinal peptide (VIP)-ergic neurons in the ventral SCN only a small subpopulation expresses V1a, and we demonstrate the requirement of V1a in these VIP neurons for maintaining the robustness of the circadian clock using a jet-lag paradigm. Notably, we found that V1a expression appears to be minimal in the other major ventral neuronal population expressing gastrin-releasing peptide (GRP). The identified heterogeneity between VIP and GRP neurons, and among VIP neurons, provides a basic map for understanding the cryptic network structure from dorsal AVP neurons to receiver ventral SCN.
|
| Volume |
9(1)
|
| Published |
2026-2-12
|
| DOI |
10.1038/s42003-026-09694-9
|
| PII |
10.1038/s42003-026-09694-9
|
| PMID |
41680426
|
| PMC |
PMC13009381
|
| MeSH |
Animals
Arginine Vasopressin / metabolism
Circadian Rhythm
Gastrin-Releasing Peptide* / genetics
Gastrin-Releasing Peptide* / metabolism
Male
Mice
Mice, Inbred C57BL
Neurons* / metabolism
Receptors, Vasopressin* / genetics
Receptors, Vasopressin* / metabolism
Signal Transduction*
Suprachiasmatic Nucleus* / cytology
Suprachiasmatic Nucleus* / metabolism
Suprachiasmatic Nucleus* / physiology
Vasoactive Intestinal Peptide* / metabolism
|
| Resource |
| Mice |
RBRC10694 |
