論文 - 詳細
| RRC ID | 87254 |
|---|---|
| 著者 | Jiang X, Ichinose S, Ogawa T, Yonezawa K, Shimizu N, Hirokawa N. |
| タイトル | The KIF3B/B/KAP3 tail domain specifically facilitates TRIM46 transport to the axon initial segment. |
| ジャーナル | J Cell Biol |
| Abstract |
Intracellular transport is essential for neuronal organization, yet how motor proteins achieve cargo selectivity remains incompletely understood. Kinesin-2 motors transport diverse cargos through the heterotrimeric KIF3/KAP3 complex, but whether variations in assembly composition contribute to functional specificity has been unclear. This study provides evidence for heterogeneity in neuronal KIF3/KAP3 assemblies, including a KIF3B-enriched, KAP3-associated population in addition to the canonical KIF3A/B/KAP3 complex. Biochemical and cellular analyses support a preferential association between this KIF3B-enriched assembly and TRIM46, a protein required for axon initial segment organization. Structural analyses further suggest that differences in tail conformation accompany distinct assembly states and may underlie cargo selectivity. Together, these findings support a model in which compositional and structural diversity within kinesin-2 complexes contributes to spatially regulated transport during neuronal development. |
| 巻・号 | 225(5) |
| 公開日 | 2026-5-4 |
| DOI | 10.1083/jcb.202503138 |
| PII | 281711 |
| PMID | 41910726 |
| MeSH | Animals Axon Initial Segment* / metabolism Axonal Transport* Axons* / metabolism Humans Kinesins* / chemistry Kinesins* / genetics Kinesins* / metabolism Mice Nerve Tissue Proteins* / chemistry Nerve Tissue Proteins* / genetics Nerve Tissue Proteins* / metabolism Neurons / metabolism Protein Domains Protein Transport Tripartite Motif Proteins* / chemistry Tripartite Motif Proteins* / genetics Tripartite Motif Proteins* / metabolism |
| IF | 8.811 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 30 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 77.2 |
| リソース情報 | |
| ヒト・動物細胞 | NB2a(RCB2639) |