論文 - 詳細
| RRC ID | 87319 |
|---|---|
| 著者 | Uchimura K, Fujimoto Y, Endo H, Kumagai M. |
| タイトル | Marine terpenoids with antimelanogenic activity from the brown alga Dictyopteris polypodioides in B16 melanoma cells. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
The brown alga Dictyopteris polypodioides produces a variety of sesquiterpene derivatives. However, its potential as an antimelanogenic agent remains unclear. In this study, we investigated the ability of D. polypodioides extract and its constituent compounds to inhibit melanin biosynthesis. Methanolic extracts of D. polypodioides significantly suppressed melanin accumulation in B16 melanoma 4A5 cells. We identified four sesquiterpene hydroquinone derivatives, zonarol (1), yahazunol (2), isozonarol (3), and chromazonarol (6), as active constituents. Structure-activity relationship analyses, including those of semisynthetic analogs, indicated that the hydroquinone moiety is crucial for the antimelanogenesis activity. Chromazonarol (6), which lacks a hydroquinone group, inhibits tyrosinase (monophenolase) in an uncompetitive manner, with 50% inhibitory concentration of 6.2 µm. Quantitative analysis revealed that these sesquiterpene derivatives accounted for approximately 5.6% of the dried algal biomass. D. polypodioides is a promising natural source of bioactive compounds with potential applications in preventing melanogenesis and food browning. |
| 巻・号 | 90(2) |
| ページ | 166-172 |
| 公開日 | 2026-1-24 |
| DOI | 10.1093/bbb/zbaf167 |
| PII | 8317223 |
| PMID | 41206742 |
| MeSH | Animals Cell Line, Tumor Melanins* / antagonists & inhibitors Melanins* / biosynthesis Melanoma, Experimental* / metabolism Melanoma, Experimental* / pathology Mice Monophenol Monooxygenase / antagonists & inhibitors Monophenol Monooxygenase / metabolism Phaeophyceae* / chemistry Sesquiterpenes / chemistry Sesquiterpenes / isolation & purification Sesquiterpenes / pharmacology Structure-Activity Relationship Terpenes* / chemistry Terpenes* / isolation & purification Terpenes* / pharmacology |
| IF | 1.516 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |