Reference - Detail
| RRC ID | 87356 |
|---|---|
| Author | Shiiba N, Matsuda A, Tsuruta T, Nishikawa K, Morimoto Y, Kumagai M. |
| Title | Conformational Dynamics and Osteoclastogenesis Inhibition by Cladiellin-Type Diterpenes from the Marine Gastropod Ovula ovum. |
| Journal | J Nat Prod |
| Abstract |
A cladiellin-type diterpene, 3-O-deacetylcladiellin (1), was isolated from the marine gastropod Ovula ovum, together with a known analogue 2. The NMR spectra of 1 and 2 exhibited unusually broad resonances. The structure and absolute configuration of 1 were unambiguously established by X-ray crystallographic analysis and electronic circular dichroism spectroscopy. DFT-based conformational analysis combined with variable-temperature NMR revealed that the NMR coalescence arises from conformational exchange of the flexible nine-membered ring. Chemical evidence suggests that 1 is likely derived from an unidentified soft coral prey of O. ovum. Compound 1 inhibits RANKL-induced osteoclast differentiation in RAW264 cells. |
| Volume | 89(3) |
| Pages | 1093-1099 |
| Published | 2026-3-27 |
| DOI | 10.1021/acs.jnatprod.6c00102 |
| PMID | 41804541 |
| MeSH | Animals Crystallography, X-Ray Diterpenes* / chemistry Diterpenes* / isolation & purification Diterpenes* / pharmacology Gastropoda* / chemistry Magnetic Resonance Spectroscopy Mice Molecular Conformation Molecular Structure Osteoclasts* / drug effects Osteogenesis* / drug effects RAW 264.7 Cells |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) |