| RRC ID |
87403
|
| Author |
Tashiro H, Kuwahara Y, Kurihara Y, Yaguchi T, Ban S, Watanabe A, Takahashi K.
|
| Title |
Remarkable response to dupilumab in refractory allergic bronchopulmonary mycosis with a giant mucus plug due to Aspergillus udagawae.
|
| Journal |
Respir Investig
|
| Abstract |
Allergic bronchopulmonary mycosis (ABPM) is due to hypersensitivity to fungi, usually Aspergillus fumigatus, that is treated with systemic corticosteroids; it often relapses and causes adverse effects. The first case of ABPM due to Aspergillus udagawae with a giant mucus plug in a 45-year-old man whose disease and plug persisted despite 12 months of prednisolone and itraconazole, complicated by steroid-induced central serous chorioretinopathy, is reported. Changing therapy to dupilumab produced rapid clinical improvement and marked shrinkage of the plug without steroid toxicity. Dupilumab targeting IL-4/IL-13 might offer a steroid-sparing option for ABPM.
|
| Volume |
63(6)
|
| Pages |
1037-1041
|
| Published |
2025-11-1
|
| DOI |
10.1016/j.resinv.2025.08.002
|
| PII |
S2212-5345(25)00126-1
|
| PMID |
40829197
|
| MeSH |
Antibodies, Monoclonal, Humanized* / therapeutic use
Antifungal Agents / therapeutic use
Aspergillosis, Allergic Bronchopulmonary* / drug therapy
Aspergillus* / isolation & purification
Humans
Itraconazole / administration & dosage
Male
Middle Aged
Mucus*
Prednisolone / administration & dosage
Prednisolone / adverse effects
Treatment Outcome
|
| Resource |
| Pathogenic eukaryotic microorganisms |
Aspergillus udagawae IFM 68389 |
