論文 - 詳細
| RRC ID | 87487 |
|---|---|
| 著者 | Herget U, Tran S, Singh C, Oikonomou G, Ryu S, Rotllant J, Prober DA. |
| タイトル | Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons. |
| ジャーナル | Curr Biol |
| Abstract |
Classical studies identified a critical role for the hypothalamus in regulating sleep and wake states, but few such hypothalamic neuronal populations have been identified. Here, we describe a sleep-promoting population of hypothalamic neurons that expresses the neuropeptides QRFP and parathyroid hormone 4 (Pth4) in zebrafish. Optogenetic stimulation of these neurons results in a large increase in sleep that requires pth4 but not qrfp. Noradrenergic locus coeruleus (LC) neurons and serotonergic (5HT) raphe nuclei (RNs) in the hindbrain express distinct pth receptors, and genetic epistasis and cell ablation experiments revealed that Pth4 neuron-induced sleep is suppressed in mutants that lack noradrenaline in the LC or lack the 5HT RNs. Pth4 neuron-induced sleep is also suppressed in serine/threonine kinase 32a (stk32a) mutants, possibly via stk32a-expressing neurons in the prethalamus that express pth receptors. These results identify QRFP/Pth4 neurons as a novel hypothalamic sleep-promoting population and support a model in which distinct sleep- and wake-promoting hypothalamic populations act via monoaminergic neurons in the hindbrain to control vigilance state. |
| 巻・号 | 36(1) |
| ページ | 161-175.e3 |
| 公開日 | 2026-1-5 |
| DOI | 10.1016/j.cub.2025.11.052 |
| PII | S0960-9822(25)01556-8 |
| PMID | 41406966 |
| PMC | PMC12818467 |
| MeSH | Animals Brain Stem* / physiology Hypothalamus* / physiology Neurons* / metabolism Neurons* / physiology Parathyroid Hormone* / genetics Parathyroid Hormone* / metabolism Sleep* / physiology Zebrafish* / genetics Zebrafish* / physiology Zebrafish Proteins* / genetics Zebrafish Proteins* / metabolism |
| IF | 9.601 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 47.5 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(UAS:nfsB-mCherry)rw0144 |