| RRC ID |
87502
|
| 著者 |
Herrera KJ, Zarghani-Shiraz A, Ahrens MB, Engert F, Fishman MC.
|
| タイトル |
Synchronization of behavioral and cardiac dynamics in larval zebrafish.
|
| ジャーナル |
Cell Rep
|
| Abstract |
Animals reprioritize behavioral goals in response to internal physiological states. Using larval zebrafish, we investigated whether engagement with a visuomotor task, the optomotor response (OMR), is coupled to cardiac dynamics. We discovered that threats lead to tachycardia that is synchronized with behavioral suppression. The change in heart rate is represented in the activity of specific neuronal populations. Severing the input to the sympathetic ganglia or ablating the vagus nerve revealed that the threat-related changes to behavioral state do not require interoceptive pathways. Direct tachycardic optopacing of the heart similarly suppressed the OMR response, but by reducing cardiac filling during diastole, thereby impacting oxygen delivery to the CNS. Optopacing also changed the activity of specific brain regions but in neurons distinct from those associated with threat-induced tachycardia. These cardiac function-associated central changes may have relevance to autonomic imbalances in anxiety, stress, and orthostatic disorders.
|
| 巻・号 |
45(2)
|
| ページ |
116947
|
| 公開日 |
2026-2-24
|
| DOI |
10.1016/j.celrep.2026.116947
|
| PII |
S2211-1247(26)00025-2
|
| PMID |
41637187
|
| PMC |
PMC12994571
|
| MeSH |
Animals
Behavior, Animal* / physiology
Brain / physiology
Heart* / physiology
Heart Rate / physiology
Larva / physiology
Neurons / physiology
Tachycardia / physiopathology
Zebrafish* / physiology
|
| リソース情報 |
| ゼブラフィッシュ |
Tg(vglut2a:Gal4) |
