| RRC ID |
87510
|
| Author |
Kishida K, Kawakami K, Tanabe H, Nakai W, Yonekura K, Yokoyama S, Arase H.
|
| Title |
Immune-induced TCR-like antibodies regulate specific T cell response in mice.
|
| Journal |
Nat Commun
|
| Abstract |
Antigen-specific regulation of T cell response is crucial for limiting hyperimmune response. However, the molecular mechanisms governing specific immune regulation remain unclear. In this study, we discover that antibodies specific to the antigen peptide-MHC class II complex are produced during helper T cell responses to various antigens, including hen egg lysozyme and proteolipid protein peptide. These antibodies specifically inhibit T cell receptor (TCR) recognition of MHC class II molecules presenting specific antigen peptide. We term these antibodies 'immune-induced TCR-like antibodies' or iTabs. Immunization with peptides containing flanking residues induces iTabs whereas immunization with peptides lacking flanking residues does not. Furthermore, we show that immunization with iTab-inducible peptide or iTab treatment suppress autoimmune disease development in a mouse model of experimental autoimmune encephalomyelitis. Thus, our findings provide a strategy for suppressing antigen-specific helper T cell responses using specific peptides, potentially controlling autoimmune diseases.
|
| Volume |
17(1)
|
| Published |
2026-4-16
|
| DOI |
10.1038/s41467-026-71384-1
|
| PII |
10.1038/s41467-026-71384-1
|
| PMID |
41991935
|
| PMC |
PMC13087043
|
| MeSH |
Animals
Antibodies* / immunology
Encephalomyelitis, Autoimmune, Experimental* / immunology
Female
Histocompatibility Antigens Class II / immunology
Immunization
Mice
Mice, Inbred C57BL
Muramidase / immunology
Peptides / immunology
Receptors, Antigen, T-Cell* / immunology
T-Lymphocytes, Helper-Inducer* / immunology
|
| Resource |
| Human and Animal Cells |
293T(RCB2202) |
