論文 - 詳細
| RRC ID | 87524 |
|---|---|
| 著者 | Ohki T, Miyawaki S, Higa T, Yamazaki H, Okaki H, Nakajima R, Kitamura K, Nakagawa MG, Sanosaka T, Tsugawa H, Honda K, Hirata A, Goto T, Handa M, Tokutake K, Saeki S, Yamamoto M, Watanabe K, Maeda S, Takasu M, Sugiura Y, Takiuchi T, Kohyama J, Suematsu M, Hirata H. |
| タイトル | Identification of endometrial CD169+ macrophages essential for Treg cell accumulation and implantation. |
| ジャーナル | Cell Rep |
| Abstract |
Successful pregnancy requires coordinated regulation between the innate and adaptive immune systems. Regulatory T (Treg) cells are essential for establishing maternal immune tolerance to the semi-allogeneic fetus, but the innate immune cells that modulate this process remain poorly defined. Here, we identify CD169+ macrophages in the endometrium as critical regulators of Treg cell recruitment and implantation. These CD169+ macrophages are endometrial localized, exhibit an anti-inflammatory phenotype, and secrete chemokines that attract Treg cells to the endometrium. We also identified CD169+ macrophages in the human endometrium that express chemokines involved in Treg cell recruitment. Our findings identify endometrial CD169+ macrophages as key orchestrators of Treg cell accumulation at the maternal-fetal interface, providing mechanistic insight into implantation and conceptus development. |
| 巻・号 | 45(3) |
| ページ | 117040 |
| 公開日 | 2026-3-24 |
| DOI | 10.1016/j.celrep.2026.117040 |
| PII | S2211-1247(26)00118-X |
| PMID | 41712382 |
| MeSH | Animals Chemokines / metabolism Embryo Implantation* / immunology Endometrium* / cytology Endometrium* / immunology Endometrium* / metabolism Female Humans Macrophages* / immunology Macrophages* / metabolism Mice Pregnancy Sialic Acid Binding Ig-like Lectin 1* / metabolism T-Lymphocytes, Regulatory* / cytology T-Lymphocytes, Regulatory* / immunology T-Lymphocytes, Regulatory* / metabolism |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 19 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 70.8 |
| リソース情報 | |
| 実験動物マウス | RBRC04395 |