論文 - 詳細
| RRC ID | 87526 |
|---|---|
| 著者 | Kondo H, Otsuka K, Morimoto J, Arimochi H, Tsukumo SI, Yasutomo K. |
| タイトル | Loss of Dmrta1 alters CD8+ T cell activation and resistance to influenza virus infection. |
| ジャーナル | Immunohorizons |
| Abstract |
The generation and function of effector and memory CD8+ T cells are crucial for effective immune responses and long-term immunity. Using gene expression analysis, we found that doublesex- and mab-3-related transcription factor like family A1 (Dmrta1), a member of the DMRT family of transcription factors, is highly expressed in activated and memory CD8+ T cells. In this study, we investigated the role of Dmrta1 in the activation and differentiation of CD8+ T cells. The Dmrta1-deficient (Dmrta1-KO) mice showed an equivalent number of thymic and splenic T cells compared with wild-type mice. Dmrta1 deficiency in T cells resulted in impaired early activation of CD8+ but not CD4+ T cells and reduced expression of granzyme B in CD8+ T cells following influenza virus infection. Although virus-specific CD8+ T cell numbers and cytotoxicity in the lung were comparable between wild-type and Dmrta1-deficient mice during primary infection, Dmrta1-KO mice exhibited a transient accumulation of virus-specific CD8+ T cells in the spleen with reduced cytotoxic activity. Upon secondary challenge, memory CD8+ T cells from Dmrta1-KO mice showed persistent defects in granzyme B expression and cytotoxic function. These findings demonstrate that Dmrta1 modulates the early activation of naïve CD8+ T cells and supports the cytotoxic functionality of both effector and memory CD8+ T cells, particularly in secondary lymphoid organs, with significant implications for antiviral immunity. |
| 巻・号 | 9(11) |
| 公開日 | 2025-11-9 |
| DOI | 10.1093/immhor/vlaf054 |
| PII | 8317564 |
| PMID | 41208110 |
| PMC | PMC12597873 |
| MeSH | Animals CD8-Positive T-Lymphocytes* / immunology Granzymes / metabolism Immunologic Memory Lung / immunology Lung / virology Lymphocyte Activation* / immunology Mice Mice, Inbred C57BL Mice, Knockout Orthomyxoviridae Infections* / immunology Transcription Factors* / deficiency Transcription Factors* / genetics Transcription Factors* / immunology Transcription Factors* / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MDCK(RCB0995) |