論文 - 詳細
| RRC ID | 87560 |
|---|---|
| 著者 | Inagaki S, Nakamura N, Kadota M, Keeley SD, Kuraku S, Sato M, Nakagawa S, Mito M, Nyberg KG, Niimi K, Kiyosawa H, Kobayashi S, Kageyama Y. |
| タイトル | Lobe-Less, a Long Noncoding RNA That Regulates Drosophila Mushroom Body Morphogenesis. |
| ジャーナル | Genes Cells |
| Abstract |
Long noncoding RNAs (lncRNAs) are abundantly transcribed in eukaryotes, but most of their physiological roles, especially in neural development, remain unclear due to limited in vivo studies. Here we show that Lobe-less (LOL) lncRNA of Drosophila is expressed in developing neuronal cells and is required for the development of the mushroom body, a center of memory and learning in the insect brain. lol mutant flies exhibit defective morphology of the mushroom body and axon branch patterns, as well as misregulation of neurogenic genes. LOL RNA forms nuclear puncta and genetically interacts with Polycomb group genes in the regulation of homeotic genes. These findings demonstrate that this long ncRNA plays a critical role in the epigenetic control of neural circuit formation. |
| 巻・号 | 31(1) |
| ページ | e70080 |
| 公開日 | 2026-1-1 |
| DOI | 10.1111/gtc.70080 |
| PMID | 41472614 |
| MeSH | Animals Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster* / genetics Drosophila melanogaster* / growth & development Gene Expression Regulation, Developmental Morphogenesis* / genetics Mushroom Bodies* / embryology Mushroom Bodies* / growth & development Mushroom Bodies* / metabolism Neurogenesis / genetics Neurons / metabolism RNA, Long Noncoding* / genetics RNA, Long Noncoding* / metabolism |
| IF | 1.655 |
| オルトメトリクス指標 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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