Reference - Detail
| RRC ID | 87568 |
|---|---|
| Author | Garibağaoğlu R, Kobayashi R, Hanashiro V, Tomita J, Kume K. |
| Title | The effect of L-alanine on sleep through taste properties in Drosophila melanogaster. |
| Journal | Neurosci Res |
| Abstract |
Sleep and nutrition are important for the survival of organisms. This study focuses on the effects of amino acids, specifically L-alanine, on sleep of Drosophila melanogaster. Some amino acids including L-alanine are shown to be attractive to flies. To assess their effect on sleep, either sucrose (sweet) or sorbitol (non-sweet) was used as a base sugar of the food. Sleep was measured using monitors with infrared beams, and feeding behavior was examined by food intake and proboscis extension response tests. L-alanine supplementation in a sweet diet did not alter sleep, but supplementation in a non-sweet diet increased sleep. The addition of non-nutritive sweetener, sucralose to a non-sweet diet also increased sleep, but combining sucralose with L-alanine did not produce additive effects. L-alanine also increased the lifespan of aged flies when supplemented in a non-sweet diet. These findings suggest that the attractive taste properties of L-alanine induced sleep and offer new insights into the relationship between sleep and taste. |
| Volume | 218 |
| Pages | 104924 |
| Published | 2025-9-1 |
| DOI | 10.1016/j.neures.2025.104924 |
| PII | S0168-0102(25)00107-5 |
| PMID | 40517958 |
| MeSH | Alanine* / pharmacology Animals Drosophila melanogaster / physiology Feeding Behavior / drug effects Female Longevity / drug effects Male Sleep* / drug effects Sleep* / physiology Sorbitol / pharmacology Sucrose / analogs & derivatives Sucrose / pharmacology Taste* / drug effects Taste* / physiology |
| IF | 2.645 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#150534 |