論文 - 詳細
| RRC ID | 87569 |
|---|---|
| 著者 | Ghosh N, Rojo-Iost E, Treisman JE. |
| タイトル | Curvature of the Drosophila corneal lens depends on localized chitin secretion. |
| ジャーナル | PLoS Biol |
| Abstract |
The Drosophila corneal lens is an apical extracellular matrix structure with a biconvex shape that enables it to focus light onto the underlying photoreceptors. Here, we investigated how this shape is influenced by the source of one of its major components, the polysaccharide chitin. Knocking down the chitin synthase Krotzkopf verkehrt strongly reduced the thickness and curvature of the corneal lens. Conversely, enhancing chitin export by overexpressing Rebuf expanded and distorted the corneal lens. We found that the cone and primary pigment cells in the center of each ommatidium produce most of the chitin, and preventing chitin synthesis by these central cells reduced corneal lens curvature. Increasing chitin export from central cells increased the thickness of the central corneal lens, while increasing export from peripheral lattice cells made the edges thicker. The wild-type biconvex shape thus results from high levels of chitin production by central cells relative to peripheral cells, indicating that localized chitin secretion is critical for normal corneal lens curvature. |
| 巻・号 | 24(3) |
| ページ | e3003725 |
| 公開日 | 2026-3-1 |
| DOI | 10.1371/journal.pbio.3003725 |
| PII | PBIOLOGY-D-25-03626 |
| PMID | 41860940 |
| PMC | PMC13020976 |
| MeSH | Animals Chitin* / metabolism Chitin Synthase / genetics Chitin Synthase / metabolism Drosophila* / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster* / anatomy & histology Drosophila melanogaster* / metabolism Lens, Crystalline* / anatomy & histology Lens, Crystalline* / metabolism |
| IF | 7.076 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 44 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 24.9 |
| リソース情報 | |
| ショウジョウバエ | DGRC#115238 |