Reference - Detail
| RRC ID | 87575 |
|---|---|
| Author | Chung PC, Ku KY, Chu SY, Chen C, Yu HH. |
| Title | Genetic network shaping Kenyon cell identity and function in Drosophila mushroom bodies. |
| Journal | Elife |
| Abstract |
Revealing the molecular mechanisms underlying neuronal specification and acquisition of specific functions is key to understanding how the nervous system is constructed. In the Drosophila brain, Kenyon cells (KCs) are sequentially generated to assemble the backbone of the mushroom body (MB). Broad-complex, tramtrack, and bric-ȧ-brac zinc finger transcription factors (BTBzf TFs) specify early-born KCs, whereas the essential TFs for specifying late-born KCs remain unidentified. Here, we report that Pipsqueak domain-containing TF Eip93F promotes the identity of late-born KCs by reciprocally regulating gene expression in main KC types. Moreover, Eip93F not only regulates the expression of calcium channel Ca-α1T in late-born KCs to functionally control animal behavior, but it also forms a genetic network with BTBzf TFs to specify the identities of main KC types. Our study provides crucial information linking KC-type diversification to unique function acquisition in the adult MB. |
| Volume | 14 |
| Published | 2026-2-27 |
| DOI | 10.7554/eLife.108173 |
| PII | 108173 |
| PMID | 41758548 |
| PMC | PMC12948353 |
| MeSH | Animals Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster* / genetics Gene Regulatory Networks* Mushroom Bodies* / cytology Mushroom Bodies* / physiology Neurons* / physiology Transcription Factors / genetics Transcription Factors / metabolism |
| IF | 7.08 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.5 |
| Resource | |
| Drosophila | DGRC#115308 DGRC#115455 DGRC#115505 DGRC#115623 |