Reference - Detail
| RRC ID | 87586 |
|---|---|
| Author | Soltani S, Yan M, Yu Q, Abd Elhafiz A, Pfriem E, Webb SM, Kroll T, Bahena Lopez JM, Missirlis F, King-Jones K. |
| Title | New molecular components of high and low affinity iron import systems in Drosophila. |
| Journal | Nat Commun |
| Abstract |
The high abundance and molecular versatility of iron have led to its universal presence in biological systems, yet its absorption is exceptionally challenging. Animals and yeasts use divalent metal transporters to import iron, but yeasts also employ the multicopper oxidase Fet3p for high-affinity iron uptake when iron-starved. Using long-term iron depletion in Drosophila, we identified four components involved in iron absorption: Multicopper oxidase-4 (Mco4), a Fet3p ortholog, is essential for surviving iron starvation, whereas the cytochrome b561 enzymes Fire (Ferric Iron Reductase) and Fire-like, as well as cytochrome b5 protein Firewood, are required for iron absorption under normal conditions. This study reports the presence of a high-affinity iron uptake system in an animal, a cytochrome b5 electron donor for ferric iron reduction, and intestinal ferric reductases, and provides a valuable resource for further exploration of genes involved in iron homeostasis, transport, and absorption. |
| Volume | 16(1) |
| Pages | 5662 |
| Published | 2025-7-1 |
| DOI | 10.1038/s41467-025-60758-6 |
| PII | 10.1038/s41467-025-60758-6 |
| PMID | 40592826 |
| PMC | PMC12218971 |
| MeSH | Animals Biological Transport Cytochromes b5 / genetics Cytochromes b5 / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster* / genetics Drosophila melanogaster* / metabolism FMN Reductase / genetics FMN Reductase / metabolism Iron* / metabolism Oxidoreductases / genetics Oxidoreductases / metabolism |
| IF | 12.121 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 13 |
| Altmetric score changes over past 6months | 2.3 |
| Resource | |
| Drosophila | DGRC#113094 |