論文 - 詳細
| RRC ID | 87616 |
|---|---|
| 著者 | Zhang S, Lin H, Yu J, Wu Y, Wang C, Mao L, Jin Y, Geng Q, Jiang S, Shen X, Ge C, Chen T, Li J, Li J, Xiao X, Li H. |
| タイトル | Nebivolol Inhibits Hepatocellular Carcinoma via RHOQ and Enhances the Efficacy of Lenvatinib. |
| ジャーナル | Int J Biol Sci |
| Abstract |
Hepatocellular carcinoma (HCC) is associated with high mortality due to late diagnosis, recurrence, and limited therapeutic options. Thus, there is an urgent need for novel treatment approaches and new therapeutic targets. Cardiotoxicity resulting from anticancer therapies has become increasingly prominent, leading to a higher risk of cardiovascular diseases among cancer survivors. In our study, through a drug library screening, we identified that the cardiovascular therapeutic agent nebivolol exerts antitumor effects against HCC both in vivo and in vitro. Mechanistically, nebivolol suppressed HCC progression by downregulating RHOQ independently of β1-adrenergic receptors. Furthermore, the combination of nebivolol and lenvatinib synergistically inhibited HCC proliferation both in vivo and in vitro. This study provides a rationale for repurposing nebivolol as a combination strategy for HCC therapy. |
| 巻・号 | 22(7) |
| ページ | 3617-3634 |
| 公開日 | 2026-1-1 |
| DOI | 10.7150/ijbs.127395 |
| PII | ijbsv22p3617 |
| PMID | 42003931 |
| PMC | PMC13086015 |
| MeSH | Animals Antineoplastic Agents / pharmacology Antineoplastic Agents / therapeutic use Carcinoma, Hepatocellular* / drug therapy Carcinoma, Hepatocellular* / metabolism Cell Line, Tumor Cell Proliferation / drug effects Humans Liver Neoplasms* / drug therapy Liver Neoplasms* / metabolism Male Mice Mice, Inbred BALB C Mice, Nude Nebivolol* / pharmacology Nebivolol* / therapeutic use Phenylurea Compounds* / pharmacology Phenylurea Compounds* / therapeutic use Quinolines* / pharmacology Quinolines* / therapeutic use |
| IF | 4.858 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| ヒト・動物細胞 | HuH-7(RCB1366) |