Reference - Detail
| RRC ID | 87621 |
|---|---|
| Author | Fusari E, Muzzopappa M, Gracia J, Milán M. |
| Title | Depletion of aneuploid cells is shaped by cell-to-cell interactions. |
| Journal | Cell Genom |
| Abstract |
Aneuploidy is pervasive in early human embryos but robustly dampened during development. Later in life, aneuploidy correlates with pathological conditions, including cancer. Identification of the mechanisms underlying the elimination of aneuploid cells is relevant in development and disease. We characterized the impact on cell proliferation and survival of a large collection of molecularly defined segmental monosomies and trisomies of different sizes and ranges of overlap. Our data reveal signs of outcompetition of cells carrying small monosomies in regions devoid of previously known haploinsufficient genes. Dose-dependent effects of single genes or a discrete number of genes contribute to the phenomenon of cell competition through different mechanisms. By simultaneously inducing cells carrying monosomies and trisomies of the same genomic location, we show that trisomies potentiate or alleviate the negative effects of monosomy on growth, thus revealing a key role of cell interactions in defining the in vivo elimination of aneuploid cells. |
| Volume | 5(8) |
| Pages | 100894 |
| Published | 2025-8-13 |
| DOI | 10.1016/j.xgen.2025.100894 |
| PII | S2666-979X(25)00150-8 |
| PMID | 40466636 |
| PMC | PMC12366656 |
| MeSH | Aneuploidy* Cell Communication* / genetics Cell Proliferation / genetics Cell Survival / genetics Humans Monosomy / genetics Trisomy / genetics |
| Resource | |
| Drosophila | DGRC#123026 DGRC#123052 DGRC#123095 DGRC#123126 DGRC#123418 DGRC#123520 DGRC#123708 DGRC#124049 DGRC#124054 DGRC#124151 DGRC#124172 DGRC#124213 DGRC#125491 DGRC#125605 DGRC#125780 DGRC#125839 DGRC#125886 DGRC#125905 DGRC#125972 DGRC#125973 DGRC#126092 DGRC#126103 DGRC#126198 DGRC#126201 DGRC#126206 DGRC#126251 DGRC#150540 |