論文 - 詳細
| RRC ID | 87628 |
|---|---|
| 著者 | Israel S, Parnas M. |
| タイトル | A new system for studying neuronal remodeling and its relation to behavior in Drosophila. |
| ジャーナル | Commun Biol |
| Abstract |
Neuronal remodeling is essential for the precise formation of mature nervous systems. Drosophila serves to study neuronal remodeling; however, existing experimental systems are insufficient for examining circuit-level neuronal remodeling and its effect on behavior. We present a new model system to investigate neuronal remodeling. We show that the Moonwalker SEZ neuron, which elicits backward walking in adult flies, is part of a conserved circuit persisting from larva to adult. Utilizing the system, we examine developmental neuronal remodeling, describe a gene-regulatory mechanism controlling outgrowth, and uncover a causal relation between remodeling and behavior. The well-characterized connectivity of the circuit, low number of elements, direct control of the motor output, and availability of specific driver lines, provide an appealing system to study developmental remodeling of neuronal circuits and their impact on behavior. Hence, we establish a new model system in Drosophila to investigate neural circuit remodeling and its relation to behavior. |
| 巻・号 | 8(1) |
| ページ | 1830 |
| 公開日 | 2025-12-22 |
| DOI | 10.1038/s42003-025-09344-6 |
| PII | 10.1038/s42003-025-09344-6 |
| PMID | 41429933 |
| PMC | PMC12749610 |
| MeSH | Animals Behavior, Animal* / physiology Drosophila* / physiology Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster* / genetics Drosophila melanogaster* / growth & development Drosophila melanogaster* / physiology Larva / physiology Neuronal Plasticity* / physiology Neurons* / physiology |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#104937 DGRC#112095 |