論文 - 詳細
| RRC ID | 87631 |
|---|---|
| 著者 | Lyu C, Li Z, Xu C, Wong KKL, Luginbuhl DJ, McLaughlin CN, Xie Q, Li T, Li H, Luo L. |
| タイトル | Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit. |
| ジャーナル | Science |
| Abstract |
A navigating axon faces complex choices when selecting postsynaptic partners in a three-dimensional (3D) space. In this work, we discovered a principle that can establish the 3D glomerular map of the fly antennal lobe by reducing the higher dimensionality serially to 1D projections. During development, olfactory receptor neuron (ORN) axons first contact their partner projection neuron dendrites on the spherical surface of the antennal lobe, regardless of whether the adult glomeruli lie near the surface or inside. Along this 2D surface, axons of each ORN type take a specific, arc-shaped trajectory that precisely intersects with their partner dendrites. Altering axon trajectories compromises synaptic partner matching. A 3D search is thus reduced to one dimension, simplifying partner matching. |
| 巻・号 | 388(6746) |
| ページ | 538-544 |
| 公開日 | 2025-5-1 |
| DOI | 10.1126/science.ads7633 |
| PMID | 40310920 |
| PMC | PMC12614222 |
| MeSH | Animals Arthropod Antennae* / innervation Arthropod Antennae* / physiology Axons / physiology Axons / ultrastructure Dendrites / physiology Dimensionality Reduction Drosophila melanogaster* / growth & development Drosophila melanogaster* / physiology Olfactory Pathways* / physiology Olfactory Receptor Neurons* / cytology Olfactory Receptor Neurons* / physiology Synapses* / physiology |
| IF | 41.846 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#113584 DGRC#105257 |