論文 - 詳細
| RRC ID | 87649 |
|---|---|
| 著者 | Huang A, Cocconi L, Nicholls-Mindlin B, Alexandre C, Salbreux G, Vincent JP. |
| タイトル | A genetic circuit that extends the useful range of a BMP morphogen arose alongside insect wing evolution. |
| ジャーナル | Curr Biol |
| Abstract |
The range over which a morphogen gradient provides reliable positional information is limited by intrinsic noise. We identify a regulatory circuit that counteracts this constraint for Dpp, a BMP that organizes the anterior/posterior axis of Drosophila wings. The transcriptional repressor Brinker (Brk), a Dpp target, enhances positional precision by repressing Dad, an inhibitory Smad, thereby extending Dpp's effective range. Thus, Brk mediates a feedback circuit that selectively amplifies low-level Dpp signals as would a logarithmic amplifier. This circuit also achieves temporal integration, mitigating the inevitable noise penalty associated with amplification. Although a core component of BMP signaling in flies, Brk is found exclusively in insects. Phylogenetic and expression analyses in the apterygote insect Thermobia domestica suggest that Brk originated in insects and was incorporated into the BMP network in pterygotes, possibly to permit long-range signaling in wing primordia. Brk exemplifies how gene regulatory network (GRN) evolution can enhance developmental precision, thus opening the door to increased morphological complexity. |
| 巻・号 | 35(23) |
| ページ | 5840-5852.e15 |
| 公開日 | 2025-12-1 |
| DOI | 10.1016/j.cub.2025.10.059 |
| PII | S0960-9822(25)01406-X |
| PMID | 41253154 |
| MeSH | Animals Biological Evolution* Bone Morphogenetic Proteins* / genetics Bone Morphogenetic Proteins* / metabolism Drosophila* / genetics Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster* / genetics Drosophila melanogaster* / growth & development Gene Expression Regulation, Developmental Gene Regulatory Networks* Phylogeny Repressor Proteins* / genetics Repressor Proteins* / metabolism Signal Transduction Wings, Animal* / growth & development Wings, Animal* / metabolism |
| IF | 9.601 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#118137 |