Reference - Detail
| RRC ID | 87654 |
|---|---|
| Author | Wang M, Han X, Lee Y, Takayama R, Sato M. |
| Title | Src/Fas2-dependent Ephrin phosphorylation initiates Eph/Ephrin reverse signaling through Rac1 to shape columnar units in the fly brain. |
| Journal | Sci Adv |
| Abstract |
Columns are the morphological and functional units containing multiple neurons in the brain. The molecular mechanisms of column formation are largely unknown. Ephrin/Eph signaling mediates a variety of developmental processes. Ephrin acts as a ligand for Eph to regulate forward signaling, whereas Eph acts as a ligand for Ephrin to regulate reverse signaling. However, whether and how the uni- or bidirectional Ephrin/Eph signaling is involved in column formation remains elusive. In this study, we show that Ephrin and Eph regulate the morphology and location of columnar neurons through bidirectional repulsive signaling. Furthermore, Eph ligand triggers cytoplasmic tyrosine phosphorylation of Ephrin under the control of Src kinases and Fasciclin 2 (Fas2), forming the Ephrin/Src/Fas2 complex to promote reverse signaling through a downstream regulator, Rac1. This study provides the detailed analysis of the molecular interactions involved in column formation using the fly brain as a model. |
| Volume | 11(33) |
| Pages | eadv7490 |
| Published | 2025-8-15 |
| DOI | 10.1126/sciadv.adv7490 |
| PMID | 40802768 |
| PMC | PMC12346307 |
| MeSH | Animals Brain* / cytology Brain* / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster* / metabolism Ephrins* / metabolism Neurons / cytology Neurons / metabolism Phosphorylation Receptors, Eph Family* / metabolism Signal Transduction* rac1 GTP-Binding Protein* / metabolism src-Family Kinases* / metabolism |
| IF | 13.117 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | |